Lifespan based indirect response models
نویسندگان
چکیده
منابع مشابه
Integrated functions for four basic models of indirect pharmacodynamic response.
The integrated solutions (ABEC, area between baseline and effect curve) of four basic models of indirect pharmacodynamic responses are developed. These models assume that drug can inhibit or stimulate the production or loss of the response variable. For two models (I and III) with monoexponential drug disposition, explicit formulas for the ABEC were obtained, where ABEC is a function of ln (1 +...
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ژورنال
عنوان ژورنال: Journal of Pharmacokinetics and Pharmacodynamics
سال: 2012
ISSN: 1567-567X,1573-8744
DOI: 10.1007/s10928-011-9236-y